What Retatrutide is

Class and mechanism

Retatrutide is a triple GIP/GLP-1/glucagon receptor agonist. A single peptide with agonist activity at three receptors: GIP, GLP-1 and glucagon. The glucagon component is what distinguishes it from dual agonists such as tirzepatide.

Where it sits

Incretin compounds are grouped by how many receptors they act at. A single agonist works at GLP-1 alone, a dual agonist adds GIP, and a triple agonist adds glucagon. The receptor count is the clearest way to tell one from another when the names are unfamiliar.

Other names

Retatrutide is also written as LY3437943. The same molecule appears under more than one name, which is worth knowing when comparing listings between suppliers.

Others in the metabolic and GLP-1 range

Retatrutide sits in the metabolic and GLP-1 group. The compounds below share that grouping, which is the useful starting point when comparing one against another: same group means the comparison is like for like, different group usually means it is not.